연구논문

세부과제번호 2013M3A9D5072550 단계 1단계 2차년도
세부과제명 마우스 운동 및 대사표현형 분석 기반 구축 및 서비스 제공 공동 유/무 -
SCI여부 N 게재년월 201412
논문제목 Exercise-induced myokines in health and metabolic diseases
총저자명 Byunghun So, Hee-Jae Kim, Jinsoo Kim, Wook Song
학술지명 Integrative Medicine Research 게재권(호) 3(4)
저널구분 - 페이지수 172~ 179
참여연구원 송욱 연구책임자 성제경
과제기여도 10 PMID -
사사기관수 - IF (년도) -
제1저자 소병훈 교신저자 송욱
공동저자 -
초록
Skeletal muscle has been emerging as a research field since the past 2 decades. Contrac-tion of a muscle, which acts as a secretory organ, stimulates production, secretion, andexpression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstalk between different organs in an autocrine, endocrine,or paracrine fashion. Myokines are recently recognized as potential candidates for treatingmetabolic diseases through their ability to stimulate AMP-activated protein kinase signaling,increase glucose uptake, and improve lipolysis. Myokines may have positive effects onmetabolic disorders, type 2 diabetes, or obesity. Numerous studies on myokines suggestedthat myokines offer a potential treatment option for preventing metabolic diseases. Thisreview summarizes the current understanding of the positive effects of exercise-inducedmyokines, such as interleukin-15, brain-derived neurotrophic factor, leukemia inhibitoryfactor, irisin, fibroblast growth factor 21, and secreted protein acidic and rich in cysteine, onmetabolic diseases.
1과제_성제경__1.Excercise_induced_myokines_in_health_and_metabolic_deseases.pdf
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