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초록
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We investigated the effect of resistance training on irisin expression with improvement in muscle strength and
function in aged mice and human. In the mice study, 19 months old male C57BL/6 mice were randomly assigned
into two groups; control group and resistance exercise group. Ladder climbing exercisewith tail weightwas performed
3 days per week for 12 weeks. In the human study, participants (aged over 65 years) were randomly
assigned into exercise group or control group. Elastic band exercise programconsisted of 12 weeks of 1-h session
2 days perweek. In the mice study,we found an increase of irisin in serum and soleus muscle as well as improvement
in muscle strength (p=0.02) and muscle quality (p=0.03)without body composition change in training
animals. In the human study, isokinetic leg strength and grip strength were improved in the exercise group
compared to the control group without change of body composition. In addition, the level of circulating irisin
level was increased. It had a positive correlation with grip strength (R = 0.526, p = 0.002) and leg strength
(R=0.414, p=0.003) in the exercise group. Thus, resistant training might be an efficient intervention method
to increase irisin levels and prevent age-related decline in muscle function.
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