연구논문

세부과제번호 2014M3A9D5A01073658 단계 2단계 1차년도
세부과제명 마우스 골격계 표현형분석을 통한 골질환 진단 및 골격계 질환 분석 공동 유/무 N
SCI여부 Y 게재년월 2016-03
논문제목 The analysis of antioxidant expression during muscle atrophy induced by hindlimb suspension in mice.
총저자명 Tran-Non Nuoc, Suhee Kim, Sun Hee Ahn, Jin-Sil Lee, Byung-Ju Park, Tae-Hoon Lee
학술지명 J Physiol Sci 게재권(호) 67(1)
저널구분 - 페이지수 121-129
참여연구원 - 연구책임자 최제용
과제기여도 50 PMID 26971264
사사기관수 - IF (년도) 2.075
제1저자 Tran-Non Nuoc 교신저자 Tae-Hoon Lee
공동저자 Suhee Kim, Sun Hee Ahn, Jin-Sil Lee, Byung-Ju Park
초록
Oxidative stress contributes to acceleration of muscle atrophy. However, it is still not completely understood what triggers the production of reactive oxygen species (ROS) during muscle atrophy. The objective of this study was to investigate redox balance during muscle atrophy. ROS generators and antioxidants were analyzed in atrophied soleus muscles after 2 weeks of hindlimb suspension (HLS) in mice. The HLS group showed an increase in lipid peroxidation, upregulated NOX1 and NOXO1, and downregulated mitochondrial complex I subunits NDUFS5 and NDUFV2. Additionally, HLS mice demonstrated a decrease in Prdx5 and MnSOD, but an increase in GPX2 and GPX3 in both mRNA and protein levels. As expected, MnSOD activity declined in the HLS group, while GPX activity was enhanced. These results suggest that redox imbalance occurs during muscle atrophy through NOX1 activation, mitochondrial complex I deficiency, and disturbance of antioxidants. Antioxidants altered by HLS may represent potential therapeutic targets for the protection against muscle atrophy.
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