연구논문

세부과제번호 2013M3A9D5072551 단계 1단계 2차년도
세부과제명 감각기 2차 표현형분석기반 구축 및 서비스 제공 공동 유/무 Y
SCI여부 N 게재년월 2015-09
논문제목 Clinical features of obstructive sleep apnea that determine Its high prevalence in resistant hypertension.
총저자명 Hyun Jin Min, Yang-Je Cho, Chang-Hoon Kim, Da Hee Kim, Ha Yan Kim, Ji In Choi, Jeung-Gweon LEe, Sangha Park, and Hyung-Ju Cho
학술지명 Yonsei Med J 게재권(호) 56(5)
저널구분 - 페이지수 1258-65
참여연구원 Chang-Hoon Kim 연구책임자 서경률
과제기여도 20 PMID -
사사기관수 - IF (년도) 1.287(15)
제1저자 Hyun Jin Min 교신저자 Hyung-Ju Cho
공동저자 -
초록
PURPOSE: Resistant hypertension (HTN) occurs in 15-20% of treated hypertensive patients, and 70-80% of resistant hypertensive patients have obstructive sleep apnea (OSA). The characteristics of resistant HTN that predispose patients to OSA have not been reported. Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA. MATERIALS AND METHODS: Hypertensive patients (n=475) who underwent portable polysomnography were enrolled. The patients were categorized into controlled (n=410) and resistant HTN (n=65) groups. The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed. RESULTS: Out of 475 patients, 359 (75.6%) were diagnosed with OSA. The prevalence of OSA in resistant HTN was 87.7%, which was significantly higher than that in controlled HTN (73.7%). Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA. However, stepwise multivariate analyses revealed that resistant HTN was not an independent risk factor of OSA. CONCLUSION: The higher prevalence and severity of OSA in resistant HTN may be due to the association of risk factors that are common to both conditions.
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