연구논문

세부과제번호 2014M3A9D5A01073546 단계 1단계 3차년도
세부과제명 췌장 베타세포의 분화-역분화기전 규명 공동 유/무 Y
SCI여부 Y 게재년월 2016-02
논문제목 Peripheral Serotonin: a New Player in Systemic Energy Homeostasis.
총저자명 Jun NamkungHail KimSangkyu Park
학술지명 Mol. Cells 게재권(호) 38(12)
저널구분 - 페이지수 1023-1028
참여연구원 김하일 연구책임자 김하일
과제기여도 60 PMID 26628041
사사기관수 - IF (년도) 2.09
제1저자 준남경 교신저자 박상규
공동저자 -
초록
Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated adverse effects. An ancient neurotransmitter, serotonin is among those traditional pharmacological targets for anti-obesity treatment because it exhibits strong anorectic effect in the brain. However, recent studies suggest the new functions of peripheral serotonin in energy homeostasis ranging from the endocrine regulation by gut-derived serotonin to the autocrine/paracrine regulation by adipocyte-derived serotonin. Here, we discuss the role of serotonin in the regulation of energy homeostasis and introduce peripheral serotonin as a possible target for anti-obesity treatment.
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