연구논문

세부과제번호 2013M3A9D5072551 단계 1단계 3차년도
세부과제명 감각기 2차 표현형 분석 기반 구축 및 서비스 제공 공동 유/무 -
SCI여부 Y 게재년월 2015-11
논문제목 Tear Cytokines as Biomarkers for Chronic Graft-versus-Host Disease.
총저자명 Ji Won JungSoo Jung HanMi Kyung SongTae-im KimEung Kweon KimYoo Hong MinJune-Won CheongKyoung Yul Seo
학술지명 Biol. Blood Marrow Transplant. 게재권(호) 21(12)
저널구분 - 페이지수 2079-85
참여연구원 서경률 연구책임자 서경률
과제기여도 50 PMID 26303101
사사기관수 - IF (년도) 3.404
제1저자 정지원 교신저자 서경률
공동저자 -
초록
We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status. We also tested tear cytokines as biomarkers for chronic ocular GVHD severity. Forty-four patients who underwent SCT were enrolled and their diagnosis of chronic GVHD was confirmed. Ocular surface parameters and tear cytokine profiles were evaluated and the correlations between concentrations of cytokines and ocular surface parameters or several chronic ocular GVHD severity scales were evaluated. Tear interleukin (IL)-2, IL-10, IL-17α, interferon (IFN)-γ, IL-6, and tumor necrosis factor (TNF)-α were elevated in patients with chronic systemic GVHD compared with patients without chronic systemic GVHD. Receiver-operating characteristic curve analysis revealed that area under the curve (AUC) values for tear IL-10 (AUC = .795), IL-17α (AUC = .821), IL-6 (AUC = .912), and TNF-α (AUC = .910) were significantly correlated with the presence of chronic GVHD (all P < .001). Tear IL-10, IL-6, and TNF-α showed a stronger correlation with ocular surface parameters than other cytokines and these cytokines also correlated with several chronic ocular GVHD severity scales (all P < .05). Our data suggest the tear cytokines are useful biomarkers for the diagnosis of chronic GVHD after SCT and chronic ocular GVHD severity.
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