연구논문

세부과제번호 2014M3A9D5A01073789 단계 1단계 2차년도
세부과제명 마우스 면역 질환표현형 분석 기반 구축 공동 유/무 -
SCI여부 Y 게재년월 2015-02
논문제목 The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression.
총저자명 Jinwook ChoiShin JeonSeungjin ChoiKyungsoo ParkRho Hyun Seong
학술지명 Proc. Natl. Acad. Sci. U.S.A. 게재권(호) 112(7)
저널구분 - 페이지수 E718-727
참여연구원 성노현 연구책임자 성노현
과제기여도 50 PMID 25646472
사사기관수 - IF (년도) 9.674
제1저자 최진욱 교신저자 성노현
공동저자 -
초록
Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of chromatin remodeling factors for regulation of GC formation. Here, we show that the SWI/SNF chromatin remodeling complex is required for GC reactions. Mice lacking Srg3/mBaf155, a core component of the SWI/SNF complex, showed impaired differentiation of GC B and follicular helper T cells in response to T cell-dependent antigen challenge. The SWI/SNF complex regulates chromatin structure at the Blimp-1 locus and represses its expression by interacting cooperatively with Bcl-6 and corepressors. The defect in GC reactions in mice lacking Srg3 was due to the derepression of Blimp-1 as supported by genetic studies with Blimp-1-ablated mice. Hence, our study identifies the SWI/SNF complex as a key mediator in GC reactions by modulating Bcl-6-dependent Blimp-1 repression.
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