연구논문

세부과제번호 2013M3A9D5072559 단계 1단계 2차년도
세부과제명 마우스기본표현형 고속분석 기반구축운용 공동 유/무 -
SCI여부 N 게재년월 2015-03
논문제목 An age-dependent alteration of the respiratory exchange ratio in the db/db mouse.
총저자명 Hye-Min ChoiHae Rim KimEun-Kyoung KimYong Sub ByunYoung-Suk WonWon-Ki YoonHyoung-Chin KimJong-Goo KangKi-Hoan Nam
학술지명 Laboratory Animal Research 게재권(호) 31(1)
저널구분 - 페이지수 1~6
참여연구원 남기환 연구책임자 남기환
과제기여도 90 PMID 25806077
사사기관수 - IF (년도) -
제1저자 최혜민 교신저자 남기환
공동저자 -
초록
The leptin receptor-deficient db/db mouse is a rodent model of type 2 diabetes and obesity. Diabetes in db/db mice shows an age-dependent progression, with early insulin resistance followed by an insulin secretory defect resulting in profound hyperglycemia. However, there is insufficient data on agedependent changes of energy metabolism in db/db mice. We demonstrated an age-dependent decrease in the respiratory exchange ratio (RER), calculated by a ratio of VO2/VCO2, in db/db mice. The RER determined by indirect calorimetry, was 1.03 in db/db mice under 6 weeks of age, which were similar to those in heterozygote (db/+) and wild-type (+/+) mice. However, RER decreased from approximately 0.9 to 0.8 by 10 weeks of age and subsequently returned to approximately 0.9 at 22 weeks of age. The changes in RER were concurrent with the alterations in body weight and blood glucose level. However, other metabolic indicators such as glucose tolerance, changes in body fat mass, and urinary glucose levels, did not change with age. The results suggested that the energy source utilized in db/db mice changed with the age-related progression of diabetes.
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