초록
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Skeletal muscle has been emerging as a research field since the past 2 decades. Contrac-tion of a muscle, which acts as a secretory organ, stimulates production, secretion, andexpression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstalk between different organs in an autocrine, endocrine,or paracrine fashion. Myokines are recently recognized as potential candidates for treatingmetabolic diseases through their ability to stimulate AMP-activated protein kinase signaling,increase glucose uptake, and improve lipolysis. Myokines may have positive effects onmetabolic disorders, type 2 diabetes, or obesity. Numerous studies on myokines suggestedthat myokines offer a potential treatment option for preventing metabolic diseases. Thisreview summarizes the current understanding of the positive effects of exercise-inducedmyokines, such as interleukin-15, brain-derived neurotrophic factor, leukemia inhibitoryfactor, irisin, fibroblast growth factor 21, and secreted protein acidic and rich in cysteine, onmetabolic diseases.
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